How can we have Passover without wine? This is a question that is asked of me each year as Passover approaches. I always answer that the blessing is over the fruit of the vine and grape juice is perfectly acceptable. I then ask a different set of questions.
One is obligated to become intoxicated on Purim until one cannot distinguish between "cursed is Haman" and "blessed is Mordechai" (Talmud, Megillah 7b).