The Jerusalem-based Answers.com fired about two-thirds of its staff two months after being acquired by a private company.
Among those in Israel who lost their jobs are CEO Bob Rosenschein, who co-founded the company in 1999, and Jeff Schneiderman, its chief technical officer. Staff in the United States also is expected to be dismissed.
Answers.com, a social network website with more than 50 million registered users that ask and answer questions, had approximately 65 staffers in Israel and another 25 in the United States.
AFCV Holdings acquired Answers.com for $127 million. Answers.com had been traded on the Nasdaq exchange for six years.
As part of the cuts, the company said it would halt support of products such as 1-Click Answers, AnswerTips and Widget Gallery, and would discontinue some mobile applications.