Five Palestinians were killed in the West Bank on Friday in shootings involving both Israeli forces and a civilian who appeared to be a Jewish settler, medics and witnesses said.
Three Palestinians were killed during clashes between Israeli forces shooting live bullets and protesters throwing stones near the flashpoint city of Hebron.
In a separate incident near another protest against the ongoing conflict in Gaza, witnesses said a person in a car believed to be a settler shot dead one man and wounded three others near the city of Nablus.
The victims were walking along a main street used by both Palestinians and settlers.
Clashes between Israeli border police and Palestinian youths throwing petrol bombs and fireworks escalated. A Reuters photographer witnessed the forces shoot and kill another man.
Israeli forces also shot and wounded two protesters and a local journalist approaching a military checkpoint near a settlement beside the West Bank city of Ramallah.
The Israeli police said it was investigating the violence.
The clashes follow the killing of a Palestinian north of Jerusalem during a thousands-strong protest which was one of the largest since a Palestinian uprising which ended in 2005.
Palestinian fury has mounted after 822 Palestinians - mostly civilians, according to Palestinian medics - have been killed in nearly three weeks of cross-border fighting between Israel and Palestinian militants in Gaza. The United States and regional powers are urgently seeking a truce.